1-(2-Ethoxyethyl)-2-(1-nitrosopiperidin-4-yl)-1H-benzo[d]imidazole, also designated N-Nitroso Bilastine Impurity 7, is a structurally defined nitrosamine related to the bilastine scaffold. Its molecular formula, C16H22N4O2, and molecular weight, 302.37 g/mol, are consistent with N-nitrosation of a piperidine nitrogen within the benzimidazole-linked side chain. Such impurities are commonly associated with nitrosating conditions during synthesis or storage, and are regulated because many nitrosamines are considered potentially genotoxic under ICH M7 and related health-based limits. Trace characterization typically requires LC-MS/MS, with orthogonal confirmation by high-resolution MS or GC-MS.
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![1-(2-ethoxyethyl)-2-(1-nitrosopiperidin-4-yl)-1H-benzo[d]imidazole](https://veeprho.com/wp-content/uploads/2022/07/1-2-ethoxyethyl-2-1-nitrosopiperidin-4-yl-1H-benzo5Bd5Dimidazole-sqr.png "1-(2-ethoxyethyl)-2-(1-nitrosopiperidin-4-yl)-1H-benzo[d]imidazole")
