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357336-99-3Brivaracetam (alfaR, 4S)-Isomer

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Catalogue No.:	VE0011126
CAS No.:	357336-99-3
Mol. Formula:	C11H20N2O2
Mol. Weight:	212.29 g/mol

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Additional information on CAS 357336-99-3

Parent drug

Brivaracetam

IUPAC Name

(αR,4S)-α-Ethyl-2-oxo-4-propyl-1-pyrrolidineacetamide

Synonyms

(R)-2-((S)-2-oxo-4-propylpyrrolidin-1-yl)butanamide; 1-Pyrrolidineacetamide, alpha-ethyl-2-oxo-4-propyl-, (alphaR,4S); (R.S)-brivaracetam;Î±R,4S-Brivaracetam;Brivaracetam (alfaR;Buvacitan impurity 21;Brivaracetam Impurity 3;Brivaracetam Impurity B;Brivaracetam R,S-Isomer;Boisirtam (alfaR, 4S) isomer;Brivaracetam (alfaR, 4S)-Isomer;(2R,4S)-2-(4-propylpyrrolidin-2-one)butanamide

Description

Brivaracetam (alfaR, 4S)-Isomer, CAS 357336-99-3, is a stereoisomeric impurity associated with the pyrrolidone-derived antiepileptic agent brivaracetam. With molecular formula C11H20N2O2 and molecular weight 212.29 g/mol, it retains the same elemental composition as the parent substance but differs in absolute configuration at the chiral center, which may arise during asymmetric synthesis, epimerization, or configurational drift under process conditions. Its presence is relevant for impurity profiling because stereochemical variants can alter pharmacological selectivity and optical purity. Determination typically requires chiral LC, LC-MS/MS, or high-resolution MS, with orthogonal confirmation by NMR and, where needed, polarimetric or chiroptical methods.