178306-49-5: Ambrisentan Hydroxy Acid Impurity

Ambrisentan Hydroxy Acid Impurity (CAS No: 178306-49-5) or (R)-2-hydroxy-3-methoxy-3,3-phenylpropanoid acid is an impurity present in the ambrisentan that acts by blocking the effects of a substance called endothelin that is generated by the body in increased amounts in patients with pulmonary arterial hypertension.

Additional information

Catalogue No.

VE007958

CAS No.

178306-49-5

Molecular Formula

C16H16O4

Molecular Weight

272.3 g/mol

IUPAC Name

(R)-2-hydroxy-3-methoxy-3, 3-diphenylpropanoic acid

References

Feng, Wei-Dong, et al. “Isolation, Identification, Characterization, Synthesis and Quality Control Strategy of New Process-Related Impurities in Ambrisentan.” Journal of Pharmaceutical and Biomedical Analysis, vol. 165, Feb. 2019, pp. 325–37, https://doi.org/10.1016/j.jpba.2018.12.008.

Status

In-stock