Budesonide EP Impurity L, also designated Budesonide Related Compound L and 11-Ketobudesonide, is an oxidative degradation product of the inhaled glucocorticoid budesonide rather than a distinct synthetic excipient impurity. The structure retains the corticosteroid scaffold but contains an 11-keto function, consistent with metabolic or stress-induced oxidation at C-11. CAS 216453-74-6; molecular formula C25H32O6; molecular weight 428.52 g/mol. Its presence is evaluated in pharmacopeial impurity profiling by orthogonal chromatographic methods, typically HPLC with UV detection and LC-MS/MS for structural confirmation and trace-level quantification.
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