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257877-44-4Buspirone EP Impurity N

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Catalogue No.:	VL249006
CAS No.:	257877-44-4
Mol. Formula:	C22H32N2O4
Mol. Weight:	388.50 g/mol

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Additional information on CAS 257877-44-4

Parent drug

Buspirone

IUPAC Name

8, 8′-(butane-1, 4-diyl) bis (8-azaspiro [4, 5] decane-7, 9-dione).

Pharmacopeial Synonyms

Buspirone Related Compound N

Synonyms

8,8′-(1,4-Butanediyl)bis-8-azaspiro[4.5]decane-7,9-dione; 8-[4-(7,9-dioxo-8-azaspiro[4.5]decan-8-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione

Smiles

O=C(N(CCCCN(C(C1)=O)C(CC21CCCC2)=O)C(C3)=O)CC43CCCC4

InChI

InChI=1S/C22H32N2O4/c25-17-13-21(7-1-2-8-21)14-18(26)23(17)11-5-6-12-24-19(27)15-22(16-20(24)28)9-3-4-10-22/h1-16H2

Description

Buspirone EP Impurity N, also described as Buspirone Related Compound N, corresponds to CAS 257877-44-4 and has molecular formula C22H32N2O4 with molecular weight 388.50 g/mol. Structurally, it is a bis-spiro diketone dimer derived from two buspirone-like azaspiro[4.5]decane units linked through a butanediyl bridge, and is generally regarded as a process-related impurity rather than a hydrolytic degradant. Its occurrence may reflect coupling or over-alkylation events during synthesis of the azaspiro scaffold. Due to its structural similarity to the parent API, identification typically relies on LC-MS/MS and orthogonal LC-UV methods, with NMR confirmation when necessary.