83-73-8: Clioquinol EP Impurity C

Clioquinol EP Impurity C (CAS No: 83-73-8) or Iodoquinol is widely evaluated as a potent compound for therapy of amebiasis. Iodoquinol is also a broad-spectrum anti-tumor lead. It is a potent inhibitor of moderate to high potency on an in-house MCF-7 cell line and depicts its function by reducing NAD levels in MCF-7 cells in concentrations equivalent to half of their IC50s.

Additional information

Catalogue No.

VE006810

CAS No.

83-73-8

Molecular Formula

C9H5I2NO

Molecular Weight

396.95

IUPAC Name

5, 7-Diiodoquinolin-8-ol

Synonyms

Iodoquinol

References

Khaw, M., and C. B. Panosian. “Human Antiprotozoal Therapy: Past, Present, and Future.” Clinical Microbiology Reviews, vol. 8, no. 3, July 1995, pp. 427–39, https://doi.org/10.1128/cmr.8.3.427. ‌Chaaban, Ibrahim, et al. “Transforming Iodoquinol into Broad Spectrum Anti-Tumor Leads: Repurposing to Modulate Redox Homeostasis.” Bioorganic Chemistry, vol. 113, Aug. 2021, p. 105035, https://doi.org/10.1016/j.bioorg.2021.105035. ‌

Status

In-stock