83-73-8: Clioquinol EP Impurity C
Also known as Iodoquinol, it is widely evaluated as a potent compound for therapy of amebiasis. Iodoquinol is also a broad-spectrum anti-tumor lead. It is a potent inhibitor of moderate to high potency on an in-house MCF-7 cell line and depicts its function by reducing NAD levels in MCF-7 cells in concentrations equivalent to half of their IC50s.
Additional information on CAS 83-73-8
Khaw, M., and C. B. Panosian. “Human Antiprotozoal Therapy: Past, Present, and Future.” Clinical Microbiology Reviews, vol. 8, no. 3, July 1995, pp. 427–39, https://doi.org/10.1128/cmr.8.3.427. Chaaban, Ibrahim, et al. “Transforming Iodoquinol into Broad Spectrum Anti-Tumor Leads: Repurposing to Modulate Redox Homeostasis.” Bioorganic Chemistry, vol. 113, Aug. 2021, p. 105035, https://doi.org/10.1016/j.bioorg.2021.105035.
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