Eplerenone EP Impurity E, also designated Eplerenone 7-beta-Isomer, is a stereoisomeric related substance of the mineralocorticoid receptor antagonist eplerenone, CAS 209253-81-6. With molecular formula C24H30O6 and molecular weight 414.49 g/mol, it differs from the active substance by inversion at the C7 hydroxyl-bearing stereocenter while preserving the lactone and steroidal framework. Such isomeric impurity may arise during synthesis or epimerization under acidic or thermal stress. Its characterization typically requires orthogonal reversed-phase LC with chiral separation, LC-MS/MS, and high-field NMR, as minor stereochemical changes can significantly alter chromatographic and spectrometric behavior.
References
Lønning, P. E. “Exemestane: A Review of Its Clinical Efficacy and Safety.†The Breast, vol. 10, no. 3, June 2001, pp. 198–208, https://doi.org/10.1054/brst.2001.0293. ‌
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Always active
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
To provide the best experiences, we use technologies like cookies to store and/or access device information. Consenting to these technologies will allow us to process data such as browsing behavior or unique IDs on this site. Not consenting or withdrawing consent, may adversely affect certain features and functions.
Functional
Always active
The technical storage or access is strictly necessary for the legitimate purpose of enabling the use of a specific service explicitly requested by the subscriber or user, or for the sole purpose of carrying out the transmission of a communication over an electronic communications network.
Preferences
The technical storage or access is necessary for the legitimate purpose of storing preferences that are not requested by the subscriber or user.
Statistics
The technical storage or access that is used exclusively for statistical purposes.The technical storage or access that is used exclusively for anonymous statistical purposes. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you.
Marketing
The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
