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887769-34-8Lercanidipine Inhouse Impurity D

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Catalogue No.:	VL1010003
CAS No.:	887769-34-8
Mol. Formula:	C36H39N3O6
Mol. Weight:	609.71 g/mol

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Additional information on CAS 887769-34-8

Parent drug

Lercanidipine

IUPAC Name

2,6-Dimethyl-4-(3-nitrophenyl)-pyridine-3,5-dicarboxylic acid 3-{2-[(3,3-diphenyl propyl)methylamino]-1,1-dimethyl ethyl}ester 5-methyl ester

Pharmacopoeial Synonyms

N/A

Other Synonyms

Dehydro Lercanidipine

Smiles

O=C(C1=C(C2=CC=CC([N+]([O-])=O)=C2)C(C(OC)=O)=C(C)N=C1C)OC(C)(C)CN(CCC(C3=CC=CC=C3)C4=CC=CC=C4)C

InChI

InChI=1S/C36H39N3O6/c1-24-31(34(40)44-6)33(28-18-13-19-29(22-28)39(42)43)32(25(2)37-24)35(41)45-36(3,4)23-38(5)21-20-30(26-14-9-7-10-15-26)27-16-11-8-12-17-27/h7-19,22,30H,20-21,23H2,1-6H3

Description

Lercanidipine Inhouse Impurity D, also designated dehydro lercanidipine, CAS 887769-34-8, is an oxidized process- or degradation-related analog of the dihydropyridine calcium channel blocker lercanidipine. The molecular formula C36H39N3O6 and molecular weight 609.71 g/mol are consistent with formal dehydrogenation of the parent scaffold, with consequent alteration of the heteroaromatic oxidation state and chromatographic behavior. Such impurities are typically resolved by stability-indicating HPLC coupled to diode-array detection and confirmed by LC-MS/MS, with HRMS useful for elemental assignment. It is relevant in impurity profiling under ICH Q3A and Q3B expectations.