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Documentation

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Includes: HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, Structure Elucidation Report (SER), and additional analytical data depending on the product.

Milrinone O-Glucuronide

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Catalogue No.:	VE0025675
CAS No.:	N/A
Mol. Formula:	C18H17N3O7
Mol. Weight:	387.34 g/mol

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Additional information on

Parent drug

Milrinone

IUPAC Name

(2R,3R,4R,5S,6R)-6-((5-cyano-2-methyl-[3,4′-bipyridin]-6-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid

Smiles

O=C([C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC2=C(C#N)C=C(C3=CC=NC=C3)C(C)=N2)O1)O

InChI

InChI=1S/C18H17N3O7/c1-8-11(9-2-4-20-5-3-9)6-10(7-19)16(21-8)28-18-14(24)12(22)13(23)15(27-18)17(25)26/h2-6,12-15,18,22-24H,1H3,(H,25,26)/t12-,13-,14+,15-,18-/m1/s1

Description

Milrinone O-Glucuronide impurity is a primary glucuronide metabolite and degradation product observed during milrinone synthesis and stability testing. Thorough analytical characterization using LC-MS, LC-MS/MS and high resolution HPLC facilitates identification, structure confirmation and quantification in API and formulated drug substance. Control strategy should include validated chromatographic methods, reference standard qualification and forced degradation studies to define formation pathways and acceptable limits under ICH guidelines. Understanding its physicochemical properties, retention behavior, and potential impact on pharmacokinetics and safety supports impurity profiling, specification setting and regulatory submissions. Timely monitoring during process development and stability studies reduces risk of out of specification events.