1242137-16-1: N-Desmethyl Enzalutamide

N-Desmethyl Enzalutamide (CAS No.1242137-16-1) or 4-[3-[4-Cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluorobenzamide. Enzalutamide is a nonsteroidal antiandrogen that binds to the ligand-binding domain and has more affinity. It is used in the treatment of castration-resistant prostate cancer.

Additional information

Catalogue No.

VE006572

CAS No.

1242137-16-1

Molecular Formula

C20H14F4N4O2S

Molecular Weight

450.41

IUPAC Name

4-​[3-​[4-​Cyano-​3-​(trifluoromethyl)​phenyl]​-​5, ​5-​dimethyl-​4-​oxo-​2-​thioxo-​1-​imidazolidinyl]​-​2-​fluorobenzamide

References

"Graff, Julie N., et al. “Early Evidence of Anti-PD-1 Activity in Enzalutamide-Resistant Prostate Cancer.” Oncotarget, vol. 7, no. 33, July 2016, pp. 52810–17, https://doi.org/10.18632/oncotarget.10547. ?Schrader, Andres Jan, et al. “Enzalutamide in Castration-Resistant Prostate Cancer Patients Progressing after Docetaxel and Abiraterone.” European Urology, vol. 65, no. 1, Jan. 2014, pp. 30–36, https://doi.org/10.1016/j.eururo.2013.06.042. ?"

Status

In-stock