Stock Locations

New Jersey, USA
Czech Republic, EU
Mumbai, India

* Stock subject to availability.

Documentation

Download MSDS

Download Sample COA

Includes: HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, Structure Elucidation Report (SER), and additional analytical data depending on the product.

N-Nitroso Eltrombopag Methyl Ester Impurity

● In Stock

Catalogue No.:	VE0024474
CAS No.:	N/A
Mol. Formula:	C26H23N5O5
Mol. Weight:	485.50 g/mol

Request a quote

Add to RFQ list

Additional information on N-Nitroso Eltrombopag Methyl Ester Impurity

Parent drug

Eltrombopag

IUPAC Name

Methyl (Z)-3`-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)-1-nitrosohydrazinyl)-2`-hydroxy-[1,1`-biphenyl]-3-carboxylate

Pharmacopoeial Synonyms

N/A

Other Synonyms

N/A

Smiles

O=C(C1=CC(C2=CC=CC(N(N=O)/N=C3C(C)=NN(C4=CC=C(C)C(C)=C4)C/3=O)=C2O)=CC=C1)OC

InChI

InChI=1S/C26H23N5O5/c1-15-11-12-20(13-16(15)2)30-25(33)23(17(3)27-30)28-31(29-35)22-10-6-9-21(24(22)32)18-7-5-8-19(14-18)26(34)36-4/h5-14, 32H, 1-4H3/b28-23-

Description

N-Nitroso Eltrombopag Methyl Ester Impurity is a nitrosamine-related process impurity derived from the eltrombopag methyl ester scaffold, consistent with inadvertent nitrosation during synthesis, workup, or storage under nitrite-rich conditions. With molecular formula C26H23N5O5 and molecular weight 485.50 g/mol, it is a structurally defined N-nitroso analogue requiring heightened regulatory scrutiny because nitrosamine species are commonly treated as potential genotoxic impurities under ICH M7 principles. Characterization typically relies on LC-MS/MS for trace quantification, supported by high-resolution MS and orthogonal LC-UV methods; confirmation may require NMR and, where volatility permits, GC-MS.