N-Nitroso Olmesartan Medoxomil Impurity
It belongs to Nitrosamine impurities which are referred as as Class 1 impurities, and are potentially genotoxic, known mutagenic carcinogens by ICH M7.
Additional information on N-Nitroso Olmesartan Medoxomil Impurity
Catalogue No.
VE007896
CAS No.
N/A
Molecular Formula
C29H29N7O7
Molecular Weight
587.58 g/mol
Parent drug
Olmesartan
IUPAC Name
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-1-((2'-(1-nitroso-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-propyl-1H-imidazole-5-carboxylate
Synonyms
N/A
References
Chidella, Kartheek Srinivas, et al. “Ultra-Sensitive LC-MS/MS Method for the Trace Level Quantification of Six Potential Genotoxic Nitrosamine Impurities in Telmisartan.” American Journal of Analytical Chemistry, vol. 12, no. 06, 2021, pp. 227–40, https://doi.org/10.4236/ajac.2021.126014.
Status
Under Development
