1216817-27-4: Nicardipine Pyridine Analaog

Nicardipine Pyridine Analog (CAS No: 1216817-27-4) or Nicardipine Related Compound B is an impurity present in nicardipine given by Intravenous and oral routes may produce dose-related decreases in mean arterial blood pressure and increases in heart rate of up to 30% and 8 to 26%.

Additional information

Catalogue No.

VE007874

CAS No.

1216817-27-4

Molecular Formula

C26H28ClN3O6

Molecular Weight

513.97 g/mol

IUPAC Name

2, 6-Dimethyl-4-(3-nitrophenyl)-3, 5-pyridinedicarboxylic acid methyl 2-[methyl(phenyl methyl) amino]ethyl ester HCl

Synonyms

Nicardipine Related Compound B / Dehydro Nicardipine (HCl salt)

References

“IDENTIFICATION and CHARACTERIZATION of a NOVEL POTENTIAL DEGRADANT and DEVELOPMENT and VALIDATION of STABILITY-INDICATING RP-LC METHOD for NICARDIPINE IMPURITIES in INJECTABLE DOSAGE FORM.” Journal of Liquid Chromatography & Related Technologies, 2013, http://www.tandfonline.com/doi/abs/10.1080/10826076.2012.717056.?Sorkin, Eugene M., and Stephen P. Clissold. “Nicardipine.” Drugs, vol. 33, no. 4, Apr. 1987, pp. 296–345, https://doi.org/10.2165/00003495-198733040-00002.?

Status

In-stock