111304-31-5: Nifedipine EP Impurity C

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It is an impurity present in Nifedipine that can be considered a first-line choice in all grades of angina, especially when coronary vasospasm is the underlying cause or when hypertension and/or congestive heart failure are added complications.

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Additional information on CAS 111304-31-5

Catalogue No. VL1170003
CAS No. 111304-31-5
Molecular Formula C12H11NO5
Molecular Weight 249.23
Parent drug Nifedipine
IUPAC Name 2-[(2-nitrophenyl)methylene]-3-oxo-, methyl ester
Synonyms Methyl 2-(o-Nitrobenzylidene)acetoacetate; Methyl 2-(2'-Nitrobenzylidene)acetoacetate; 2-[(2-Nitrophenyl)methylene]-3-oxo-butanoic Acid Methyl Ester
References “Validation of an HPLC Method for Nifedipine and Its Related Substances in Raw Materials.” Journal of Liquid Chromatography, 2021, http://www.tandfonline.com/doi/abs/10.1080/01483919108049311.?Sorkin, E. M., et al. “Nifedipine a Review of Its Pharmacodynamic and Pharmacokinetic Properties, and Therapeutic Efficacy, in Ischaemic Heart Disease, Hypertension and Related Cardiovascular Disorders.” Drugs, vol. 30, no. 3, Sept. 1985, pp. 182–274, https://doi.org/10.2165/00003495-198530030-00002.?
Status In-stock

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111304-31-5: Nifedipine EP Impurity C

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