Paroxetine HCl EP Impurity A (HCl Salt)
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Documentation

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Includes: HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, Structure Elucidation Report (SER), and additional analytical data depending on the product.

1322626-23-2 / 1394842-91-1Paroxetine HCl EP Impurity A (HCl Salt)

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Catalogue No.:VL1400005
CAS No.:1322626-23-2 / 1394842-91-1
Mol. Formula:C19H22ClNO3
Mol. Weight:347.84

Additional information on CAS 1322626-23-2 / 1394842-91-1

Parent drug

Paroxetine

IUPAC Name

(3S, 4R)-3-[(1, 3-Benzodioxol-5-yloxy)methyl]-4-phenylpiperidine HCl

Pharmacopoeial Synonyms

Paroxetine HCl Hemihydrate EP Impurity A (HCl Salt); Paroxetine Related Compound B (HCl Salt)

Other Synonyms

Desfluoro Paroxetine (HCl Salt); 3-((1,3-Benzodioxol-5-yloxy)methyl)-4-phenyl-, hydrochloride (1:1), (3S,4R)

Smiles

C1CNC[C@H]([C@@H]1C2=CC=CC=C2)COC3=CC4=C(C=C3)OCO4.Cl

InChI

InChI=1S/C19H21NO3.ClH/c1-2-4-14(5-3-1)17-8-9-20-11-15(17)12-21-16-6-7-18-19(10-16)23-13-22-18;/h1-7,10,15,17,20H,8-9,11-13H2;1H/t15-,17-;/m0./s1

Description

Paroxetine HCl EP Impurity A (HCl salt), also referred to in pharmacopoeias as Paroxetine HCl Hemihydrate EP Impurity A (HCl Salt); Paroxetine Related Compound B (HCl Salt), is a meticulously characterized reference standard. It adheres to stringent regulatory guidelines, including those established by USP, EMA, JP, and BP. This product plays a vital role in Abbreviated New Drug Applications (ANDA), New Drug Applications (NDA), and the commercial manufacturing of Paroxetine. Furthermore, it is accompanied by a comprehensive Structure Elucidation Report (SER), ensuring its accuracy and reliability across various analytical applications. It is an impurity of Paroxetine, is a selective serotonin reuptake inhibitor that used to treat major depressive disorder by inhibitor of serotonin reuptake. is readily absorbed from the gastrointestinal tract.

References

Paroxetine-The Antidepressant from Hell? Probably Not, But Caution Required By Robert M Nevels, Samuel T Gontkovsky, Bryman E Williams Container: Psychopharmacology bulletin Publisher: MedWorks Media Global Year: 2016 Volume: 46 Issue: 1 URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5044489/

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