Rivaroxaban Impurity 142, CAS 59337-89-2, is a low-molecular-weight organosulfur chlorinated building-block impurity characterized by the formula C5H3ClO2S and molecular weight 162.59 g/mol. Structurally, it is consistent with a reactive chlorothiophene carboxylate-type intermediate or degradant, arising from incomplete sulfonamide construction, halogen exchange, or hydrolytic cleavage during synthesis of rivaroxaban-related process streams. Its electrophilic chloride and heteroaromatic sulfur center warrant close control under impurity profiling paradigms. Trace determination typically requires LC-MS/MS with high-resolution MS confirmation, and, when volatility or derivatization permits, GC-MS may assist structural assignment. Toxicological significance should be assessed within impurity qualification frameworks.
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