Rizatriptan EP Impurity D
It is one of impurity present in Rizatriptan, Rizatriptan is a selective agonist of serotonin type 1B and 1D receptors. stimulation of presynaptic 5-HT1D receptors, which serves to inhibit both dural vasodilation and inflammation direct inhibition of trigeminal nuclei cell excitability via 5-HT1B/1D receptor agonism in the brainstem is pharmacological activity at 5-HT2, 5-HT3 or 5-HT4 receptor subtypes or at alpha1 alpha2- beta-adrenergic, dopamine1,dopamine2; muscarinic, benzodiazepine receptors. Rizatriptan also activates 5-HT1 receptors on peripheral terminals of the trigeminal nerve innervating cranial blood vessels, which is used to treat migraines.
Additional information on Rizatriptan EP Impurity D
N, N, N-Triethyl-2-[5-(1H-1, 2, 4-triazol-1-ylmethyl)-1Hindol-3-yl]ethanaminium
Láinez, M. J. (2006). Rizatriptan in the treatment of migraine. Neuropsychiatric Disease and Treatment, 2(3), 247–259. https://doi.org/10.2147/nedt.2006.2.3.247
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