Rizatriptan EP Impurity E
It is one of impurity present in Rizatriptan, Rizatriptan is metabolized by monoamine oxidase A isoenzyme, and Rizatriptan is a selective agonist of serotonin type 1B and 1D receptors. stimulation of presynaptic 5-HT1D receptors, which serves to inhibit both dural vasodilation and inflammation direct inhibition of trigeminal nuclei cell excitability via 5-HT1B/1D receptor agonism in the brainstem is pharmacological activity at 5-HT2, 5-HT3 or 5-HT4 receptor subtypes or at alpha1 alpha2- beta-adrenergic, dopamine1,dopamine2; muscarinic, benzodiazepine receptors. which is used to treat migraines.
Additional information on Rizatriptan EP Impurity E
VE0010089
N/A
C16H21N5O2S
347.44 g/mol
Rizatriptan
N, N-Dimethyl-2-[1-(methylsulfonyl)-5-(1H-1, 2, 4-triazol-1ylmethyl)-1H-indol-3-yl]ethanamine
N/A
Oldman, A., Smith, L. A., McQuay, H. J., Moore, R. A., & Derry, S. (2001). Rizatriptan for acute migraine. Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.cd003221.pub2
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