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884330-12-5Telmisartan EP Impurity E

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Catalogue No.:	VL142006
CAS No.:	884330-12-5
Mol. Formula:	C26H24N2O4
Mol. Weight:	428.48 g/mol

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Additional information on CAS 884330-12-5

Parent drug

Telmisartan

IUPAC Name

1-[(2′-carboxy[1,1′-biphenyl]-4-yl)methyl]-4-methyl-2-propyl-1H-benzimidazole-6-carboxylic acid

Pharmacopoeial Synonyms

Telmisartan Diacid

Other Synonyms

1-[(2â€²-Carboxybiphenyl-4-yl)methyl]-4-methyl-2-propyl-1H-benzo[d]imidazole-6-carboxylic acid

Smile

O=C(C1=CC(C)=C2N=C(CCC)N(CC3=CC=C(C4=CC=CC=C4C(O)=O)C=C3)C2=C1)O

InChI

InChI=1S/C26H24N2O4/c1-3-6-23-27-24-16(2)13-19(25(29)30)14-22(24)28(23)15-17-9-11-18(12-10-17)20-7-4-5-8-21(20)26(31)32/h4-5,7-14H,3,6,15H2,1-2H3,(H,29,30)(H,31,32)

Description

Telmisartan EP Impurity E, also designated Telmisartan Diacid or Telmisartan In-House Impurity D, corresponds to the oxidative carboxylic acid degradation product of the biphenyl tetrazole antihypertensive scaffold rather than a process-related genotoxic species. Its molecular formula, C26H24N2O4, and molecular weight, 428.48 g/mol, are consistent with conversion of the benzimidazole-linked benzylic alcohol functionality to the diacid form. CAS 884330-12-5 identifies this discrete impurity in reference characterization. Detection and quantification typically require reversed-phase LC-MS/MS with high-resolution accurate-mass confirmation, supplemented by PDA and, where needed, NMR structural elucidation to discriminate it from closely related oxidative analogues.