2476859-56-8: Ticagrelor -3 Nitroso Impurity
It is an impurity present in Ticagrelor, Ticagrelor is a P2Y12 platelet inhibitor, that inhibits the formation of thromboses to reduce the risk of myocardial infarction and ischemic stroke, The P2Y12 receptor couples with Gαi2 and other Gi proteins which inhibit adenylyl cyclase.3 Gi-mediated signaling also activates PI3K, Akt, Rap1b, and potassium channels, which are used in patients with a history of myocardial infarction to prevent future myocardial infarction, stroke, and cardiovascular death.
Additional information on CAS 2476859-56-8
VE008628
2476859-56-8
C26H31F2N7O5S
591.6 g/mol
Ticagrelor
N-((1R, 2S)-2-(3, 4-difluorophenyl)cyclopropyl)-N-(3-((3aS, 4R, 6S, 6aR)-6-(2-hydroxyethoxy)-2, 2-dimethyltetrahydro-4H-cyclopenta[d][1, 3]dioxol-4-yl)-5-(propylthio)-3H-[1, 2, 3]triazolo[4, 5-d]pyrimidin-7-yl)nitrous amide
N/A
Fuller, R., & Chavez, B. (2012). Ticagrelor (brilinta), an antiplatelet drug for acute coronary syndrome. P & T : A Peer-Reviewed Journal for Formulary Management, 37(10), 562–568. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3474441/
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