2476859-56-8: Ticagrelor -3 Nitroso Impurity

Status: Under Development

It is an impurity present in Ticagrelor, Ticagrelor is a P2Y12 platelet inhibitor, that inhibits the formation of thromboses to reduce the risk of myocardial infarction and ischemic stroke, The P2Y12 receptor couples with Gαi2 and other Gi proteins which inhibit adenylyl cyclase.3 Gi-mediated signaling also activates PI3K, Akt, Rap1b, and potassium channels, which are used in patients with a history of myocardial infarction to prevent future myocardial infarction, stroke, and cardiovascular death.

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Additional information on CAS 2476859-56-8

Catalogue No. VE008628
CAS No. 2476859-56-8
Molecular Formula C26H31F2N7O5S
Molecular Weight 591.6 g/mol
Parent drug Ticagrelor
IUPAC Name N-((1R, 2S)-2-(3, 4-difluorophenyl)cyclopropyl)-N-(3-((3aS, 4R, 6S, 6aR)-6-(2-hydroxyethoxy)-2, 2-dimethyltetrahydro-4H-cyclopenta[d][1, 3]dioxol-4-yl)-5-(propylthio)-3H-[1, 2, 3]triazolo[4, 5-d]pyrimidin-7-yl)nitrous amide
Synonyms N/A
References Fuller, R., & Chavez, B. (2012). Ticagrelor (brilinta), an antiplatelet drug for acute coronary syndrome. P & T : A Peer-Reviewed Journal for Formulary Management, 37(10), 562–568. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3474441/
Status Under Development

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2476859-56-8: Ticagrelor -3 Nitroso Impurity

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