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Includes: HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, Structure Elucidation Report (SER), and additional analytical data depending on the product.
1092578-47-6Tofacitinib Impurity 62 Citrate
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| Catalogue No.: | VE008307 |
|---|---|
| CAS No.: | 1092578-47-6 |
| Mol. Formula: | C16H20N6O |
| Mol. Weight: | 312.37 g/mol |
Additional information on CAS 1092578-47-6
Parent drug
TofacitinibIUPAC Name
(3S,4S)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-1-piperidinepropanenitrileSynonyms
Tofacitinib (3S, 4S)-IsomerDescription
(3S,4S)-Tofacitinib, CAS 1092578-47-6, is a stereoisomeric impurity related to the JAK inhibitor tofacitinib and should be regarded as a process- or stereochemical impurity rather than a distinct pharmacophore. With molecular formula C16H20N6O and molecular weight 312.37 g/mol, it differs from the intended active substance only in absolute configuration at the 3 and 4 positions of the piperidine-derived framework. Such epimeric or diastereomeric species may arise from asymmetric synthesis drift, chiral pool misassignment, or racemization during late-stage transformations. Quantification generally requires chiral LC-MS/MS or enantioselective LC-UV, with orthogonal NMR confirmation when structural assignment is required.Request a Quote
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