(3R,4R)-1-Nitroso Tofacitinib

Status: In-stock

It is an impurity present in Tofacitinib, Tofacitinib is an inhibitor of Janus kinases is a group of intracellular enzymes involved in signaling pathways that affect hematopoiesis and immune cell function, prevent the body from responding to cytokine signals. by that prevents the phosphorylation and activation of STATs, the JAK-STAT signaling pathway is the transcription of cells involved in hematopoiesis and immune cell function. which works by inhibiting the JAK-STAT pathway to decrease the inflammatory response, there is evidence to suggest that it may achieve efficacy via other pathways as well.

Additional information on (3R | 4R)-1-Nitroso Tofacitinib

Catalogue No. VE009926
Molecular Formula C13H18N6O
Molecular Weight 274.33 g/mol
Parent drug Tofacitinib
IUPAC Name N-methyl-N-((3R, 4R)-4-methyl-1-nitrosopiperidin-3-yl)-5H-pyrrolo[2, 3-d]pyrimidin-4-amine
Synonyms N/A
References J. Kucharz, E., Stajszczyk, M., Kotulska-Kucharz, A., Batko, B., Brzosko, M., Jeka, S., … Wiland, P. (2018). Tofacitinib in the treatment of patients with rheumatoid arthritis: position statement of experts of the Polish Society for Rheumatology. Reumatologia/Rheumatology, 56(4), 203–211. https://doi.org/10.5114/reum.2018.77971
Status In-stock

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