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Includes: HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, Structure Elucidation Report (SER), and additional analytical data depending on the product.
477600-74-1Tofacitinib N-Descyanoacetyl Impurity
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| Catalogue No.: | VE006714 |
|---|---|
| CAS No.: | 477600-74-1 |
| Mol. Formula: | C13H19N5 |
| Mol. Weight: | 245.32 g/mol |
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Additional information on CAS 477600-74-1
Parent drug
TofacitinibIUPAC Name
N-Methyl-n-((3r, 4r)-4-methylpiperidin-3-yl)-7h-pyrrolo [2, 3-d] pyrimidin-4-amineSynonyms
Tofacitinib Amine Impurity\Tofacitinib Inhouse Impurity ADescription
Tofacitinib N-Descyanoacetyl Impurity, also designated Tofacitinib Amine Impurity, is a process-related synthetic intermediate residual associated with the construction of the tofacitinib side chain. CAS 477600-74-1, molecular formula C13H19N5, molecular weight 245.32 g/mol, identifies a basic heteroaromatic amine lacking the cyanoacetyl functionality of the parent route intermediate. It is typically monitored as a route impurity arising from incomplete acylation, deprotection, or hydrolytic conversion during manufacture. Quantification generally requires LC-MS/MS, LC-UV with orthogonal confirmation, and sometimes HRMS to resolve it from structurally related amine species under impurity control strategies aligned with ICH Q3A and M7 principles.Request a Quote
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