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Home / Catalog / Synthesis Attempts and Failure Report / N-Nitroso Osimertinib; Synthesis Attempts and Failure Report (NAP Test)
N-Nitroso Osimertinib; Synthesis Attempts and Failure Report (NAP Test)
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Documentation

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内容: HPLC、MASS/LC-MS、1H NMR、FT-IR、含量、構造解析レポート（SER）、および製品に応じた追加分析データ。

N-Nitroso Osimertinib; Synthesis Attempts and Failure Report (NAP Test)

● Report Available Immediately

カタログ番号:VE0028444
CAS番号:N/A
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1 Digital Report (PDF) $1,774.73
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に関する追加情報

SMILES

C=CC(NC1=CC(N(C2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)N=O)=C(OC)C=C1N(CCN(C)C)C)=O

Experiments

10 synthesis attempts (5 experiments performed twice) under recommended conditions for nitroso impurity formation. Along with HPLC, MASS/LCMS, NMR, IR performed for all 10 synthesis attempts

Report Format

Delivered in digital PDF format. Printed copies available on request (additional shipping and handling charges apply).

Report Language

English by default.Report Language Certified translations available at extra cost via our third-party translation partner.

説明

N-Nitroso Osimertinib는 종양학에서 사용되는 EGFR tyrosine kinase 억제제인 osimertinib 관련 제안된 니트로사민 불순물입니다. 이 불순물은 산성 조건에서 니트로화제(예: 아질산염/아질산)의 존재하에 해당 N-니트로소 유도체를 형성할 수 있는 니트로화 가능한 질소 함유 또는 니트로화 가능한 부분 구조의 잠재적 니트로화 산물로 간주됩니다.

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