Naphazoline EP Impurity B, CAS 86-87-3 は、分子式 C12H10O2、分子量 186.21 の中性芳香族含酸素不純物である。構造的には、反応性の高い変異原性種というより、ベンジル位またはアリールエーテル様の分解生成物、あるいは製造由来副生成物に整合する。薬局方の文脈では、ナファゾリン製剤の類縁物質プロファイルの一部として管理される。検出および定量には、通常、逆相 HPLC による分離を基本とし、LC-MS または GC-MS による確認、必要に応じて参照標準との NMR 比較による異性体酸素化芳香族の識別が求められる。
References
Rajan, S. S. “1-Naphthaleneacetic Acid.†Acta Crystallographica Section B Structural Crystallography and Crystal Chemistry, vol. 34, no. 3, Mar. 1978, pp. 998–1000, https://doi.org/10.1107/s0567740878004641 HURWITZ, P., and J. M. THOMPSON. “USES of NAPHAZOLINE (PRIVINE(R)) in OPHTHALMOLOGY.†Archives of Ophthalmology, vol. 43, no. 4, Apr. 1950, pp. 712–17, https://doi.org/10.1001/archopht.1950.00910010723008.
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