It is an impurity present in Nilotinib which states that the anti-tumor activity and safety of nilotinib that is a KIT inhibitor utilized in the patients with metastatic melanoma harboring KIT alterations which are either mutations or amplifications.
References
Kondra, S. B., et al. “A Validated Stability-Indicative UPLC Method for Nilotinib Hydrochloride for the Determination of Process-Related and Degradation Impurities.” Journal of Chromatographic Science, vol. 52, no. 8, Sept. 2013, pp. 880–85, https://doi.org/10.1093/chromsci/bmt134.?Cho, Jin Hyun, et al. “Nilotinib in Patients with Metastatic Melanoma Harboring KIT Gene Aberration.” Investigational New Drugs, vol. 30, no. 5, Nov. 2011, pp. 2008–14, https://doi.org/10.1007/s10637-011-9763-9.?
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