It is one of impurity present in Abacavir, Abacavir is an antiviral nucleoside reverse transcriptase inhibitor with activity against Human Immunodeficiency Virus Type 1. which is phosphorylated to active metabolites. They inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis. which is a carbocyclic synthetic nucleoside analog and an antiviral agent, abacavir is converted by cellular enzymes to the active metabolite carbovir triphosphate an analog of deoxyguanosine-5'-triphosphate, inhibits the activity of HIV-1 reverse transcriptase. which is used to treat HIV and AIDS.
References
Ann, H., Kim, K.-H., Choi, H.-Y., Chang, H.-H., Han, S. H., Kim, K.-H., … Kim, S.-W. (2017). Safety and Efficacy of Ziagen (Abacavir Sulfate) in HIV-Infected Korean Patients. Infection & Chemotherapy, 49(3), 205. https://doi.org/10.3947/ic.2017.49.3.205
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