2-Amino-9-(((2-hydroxyethoxy)methoxy)methyl)-1,9-dihydro-6H-purin-6-one compound with 2-amino-9-((2-(hydroxymethoxy)ethoxy)methyl)-1,9-dihydro-6H-purin-6-one (1:1)
동의어
N/A
설명
Acyclovir EP Impurity Q는 분자식 C18H26N10O8, 분자량 510.46의 구조 유사 뉴클레오시드 불순물이다. 그 조성은 고도로 기능화된 구아닌 유래 유사체를 시사하며, 단순한 공정 잔류물보다는 산화된 또는 과아실화된 합성 부산물로 해석하는 것이 타당하다. 이러한 종은 아시클로비르 제조에서 사용되는 다단계 보호기 도입, 글리코실화, 최종 탈보호 과정에서 생성될 수 있다. 인접한 퓨린계 불순물은 함량 측정의 특이성과 불순물 프로파일에 영향을 줄 수 있으므로, 특성 규명에는 일반적으로 역상 LC와 고해상도 MS의 결합이 필요하며, MS/MS 단편화 분석과 미량 분리를 위한 LC-UV의 병행이 자주 요구된다.
References
O’Brien, John J., and Deborah M. Campoli-Richards. “Acyclovir.†Drugs, vol. 37, no. 3, Mar. 1989, pp. 233–309, 10.2165/00003495-198937030-00002.
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