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포함 사항: HPLC, MASS/LC-MS, 1H NMR, FT-IR, 함량, 구조 규명 보고서(SER), 그리고 제품에 따라 추가 분석 데이터가 제공됩니다.

906552-18-9Atorvastatin Pyrrolidone Analog (Free Base)

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카탈로그 번호:	VE006732
CAS 번호:	906552-18-9
분자식:	C33H35FN2O6
분자량:	574.25 g/mol

견적 요청

RFQ 목록에 추가

에 대한 추가 정보 CAS 906552-18-9

모약물

Atorvastatin

IUPAC명

(3R,5R)-7-[5-(4-fIuorophenyI)-2-oxo-4-phenyI-3-(phenyIcarbamoyI)-3-(propan-2-yI)-2,3-dihydro-1H-pyrroI-1- yI]-3,5-dihydroxyheptanoic acid

Pharmacopeial Synonyms

Atorvastatin EP Impurity Q

Other Synonyms

Atorvastatin Lactam Impurity; Atorvastatin Oxo Impurity; (3R,5R)-7-[5-(4-Fluorophenyl)-3-isopropyl-2-oxo-4-phenyl-3-(phenylcarbamoyl)-2,3-dihydro-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid

SMILES

O=C(C1(C(C)C)C(C2=CC=CC=C2)=C(C3=CC=C(F)C=C3)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C1=O)NC4=CC=CC=C4

InChI

InChI=1S/C34H37FN2O6/c1-22(2)34(32(42)36-26-11-7-4-8-12-26)30(23-9-5-3-6-10-23)31(24-13-15-25(35)16-14-24)37(33(34)43)20-19-28(39)21-27(38)17-18-29(40)41/h3-16,22,27-28,38-39H,17-21H2,1-2H3,(H,36,42)(H,40,41)

설명

Atorvastatin Pyrrolidone Analog also known as Atorvastatin EP Impurity Q , in various pharmacopoeias, is a highly characterized standard. It meets strict regulatory requirements set by USP, EMA, JP, and BP, making it a crucial component in Abbreviated New Drug Applications (ANDA), New Drug Applications (NDA), and the commercial production of Atorvastatin. Also known as Atorvastatin lactam, it is HMG-CoA reductase inhibitors are lipid-lowering medications used in the primary and secondary prevention of coronary heart disease.

References

Ramkumar, Satish, et al. â€œStatin Therapy: Review of Safety and Potential Side Effects.â€ Acta Cardiologica Sinica, vol. 32, no. 6, Taiwan Society of Cardiology, 2016, pp. 631â€“39, https://doi.org/10.6515/ACS20160611A. McIver, Lindsey A., and Momin S. Sid ique. â€œAtorvastatin.â€ Nih.gov, StatPearls Publishing, 5 Jan. 2019, www.ncbi.nlm.nih.gov/books/NBK430779/.