Buspirone EP Impurity E, 즉 Buspirone Open Ring Impurity는 아자스피로데칸디온계 항불안제 buspirone의 구조가 규정된 공정 기원 불순물로, CAS 257877-43-3이다. 이는 피리미디닐-피페라지닐 골격의 절단 또는 불완전한 고리화로 인해 합성 중 또는 가수분해성 분해 조건에서 생성될 수 있는 개방쇄 아마이드-피페라진 유사체이다. 분자식은 C21H33N5O3, 분자량은 403.52 g/mol이다. 미량 수준의 존재와 모약물과의 높은 구조적 유사성 때문에, 동정 및 정량에는 일반적으로 LC-MS/MS, 고분해능 MS, 그리고 UV 또는 CAD 검출을 병용한 직교 RP-HPLC가 요구된다.
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