A impureza EP E de buspirona, também denominada impureza de anel aberto da buspirona, é uma impureza de प्रक्रिया definida do ansiolítico azaspirodecanodiona buspirona, CAS 257877-43-3. Trata-se de um análogo amida-piperazina de cadeia aberta, formado por clivagem ou ciclização incompleta do esqueleto piperazinil-pirimidinil durante a síntese ou em condições degradativas hidrolíticas. A substância apresenta fórmula C21H33N5O3 e massa molecular de 403.52 g/mol. Devido à sua ocorrência em traços e à elevada semelhança estrutural com o fármaco de origem, a caracterização normalmente exige LC-MS/MS, MS de alta resolução e HPLC de fase reversa ortogonal com deteção UV ou CAD para identificação e quantificação inequívocas.
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