La impureza EP E de buspirona, también denominada impureza de anillo abierto de buspirona, es una impureza de proceso estructuralmente definida del ansiolítico azaspirodecandiónico buspirona, CAS 257877-43-3. Corresponde a un análogo amida-piperazina de cadena abierta originado por escisión o ciclación incompleta del núcleo piperazinil-pirimidinilo durante la síntesis o bajo condiciones degradativas hidrolíticas. Presenta fórmula C21H33N5O3 y peso molecular de 403.52 g/mol. Debido a su presencia a nivel traza y a su estrecha similitud estructural con el principio activo, su caracterización suele requerir LC-MS/MS, MS de alta resolución y HPLC de fase reversa ortogonal con detección UV o CAD para su identificación y cuantificación inequívocas.
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