Buspirone EP Impurity M, 즉 Buspirone Bromobutyl Analog, CAS 80827-62-9는 분자식 C13H20BrNO2, 분자량 302.21 g/mol의 브로민화 공정 유래 불순물이다. 구조적으로는 부스피론 골격의 알킬화 유사체로서, 대응하는 측쇄 모티프가 브로모부틸 치환기로 대체된 형태이며, 합성 중간체 취급 단계 또는 할로겐화 부반응에서 생성되는 경로와 부합한다. 모화합물과의 물리화학적 유사성 때문에 미량 수준의 분리와 정량에는 LC-MS/MS, 고분해능 LC-MS, 그리고 선택적 UV 또는 MS 검출을 사용하는 정교한 HPLC 방법이 일반적으로 필요하다. 이러한 특성은 불순물 프로파일링과 ICH M7 기반 평가에서 중요하다.
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