Capivasertib Nitroso Impurity 1은 AKT 억제제 capivasertib와 연관된 니트로소아민 계열 공정 불순물로, 분자식 C10H17N3O5 및 분자량 259.26 g/mol을 갖는다. 니트로소 작용기는 이 물질을 잠재적 유전독성 불순물 범주에 포함시키며, ICH M7 원칙과 니트로사민 규제 체계에 따라 평가되어야 한다. 생성 경로로는 니트로소화 부반응, 시약의 carryover, 또는 민감한 아민 함유 중간체의 분해가 거론된다. 극미량 수준의 규명을 위해서는 LC-MS/MS, 고분해능 MS, 그리고 휘발성이 허용될 경우 GC-MS가 통상 필요하다. 극성 헤테로원자 풍부 구조는 크로마토그래피 선택성과 이온화 거동을 복잡하게 만든다.
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