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포함 사항: HPLC, MASS/LC-MS, 1H NMR, FT-IR, 함량, 구조 규명 보고서(SER), 그리고 제품에 따라 추가 분석 데이터가 제공됩니다.

120014-30-4Donepezil EP Impurity A

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카탈로그 번호:	VE006102
CAS 번호:	120014-30-4
분자식:	C17H23NO3
분자량:	289.4 g/mol

견적 요청

RFQ 목록에 추가

에 대한 추가 정보 CAS 120014-30-4

모약물

Donepezil

IUPAC명

5, 6-Dimethoxy-2-(piperidin-4-ylmethyl) indan-1-one

약전 동의어

Desbenzyl Donepezil

Other Synonyms

5,6-dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one; 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-(4-piperidinylmethyl)-; 5,6-dimethoxy-2-(piperidin-4-ylmethyl)-2,3-dihydroinden-1-one; 5,6-Dimethoxy-2-piperidin-4-ylmethyl-indan-1-one; 4-((5,6-Dimethoxy-1-oxoindan-2-yl)methyl)piperidine;(acetyloxy)tributyl-Stannane;

SMILES

O=C1C(CC2CCNCC2)CC3=C1C=C(OC)C(OC)=C3

InChI

InChI=1S/C24H20N6O3/c1-2-33-23(31)19-8-5-9-20-21(19)30(24(32)25-20)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-26-28-29-27-22/h3-13H,2,14H2,1H3,(H,25,32)(H,26,27,28,29)

Shipping Condition

Ambient Temperature

Characterization Data (Included)

HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, and Structure Elucidation Report (SER).

Additional Characterization Data

QNMR, D2O Exchange, 13C NMR, 13C APT, COSY NMR, NOESY NMR, 15N NMR, HSQC NMR, HMQC NMR, and HMBC NMR. These are available upon request and may be free or subject to additional charges.

설명

Donepezil EP Impurity A known in pharmacopoeias as Desbenzyl Donepezil is a thoroughly characterized reference standard. It meets strict regulatory standards including those set by USP EMA JP and BP. This product is crucial for use in Abbreviated New Drug Applications (ANDA) New Drug Applications (NDA) and the commercial production of Donepezil. Additionally it comes with a detailed Structure Elucidation Report (SER) ensuring its precision and dependability for a variety of analytical uses. Also known as Desbenzyl Donepezil (free base ), it is a process-related impurity of Donepezil drug which is a specific, selective, and potent inhibitor of acetylcholinesterase an approved drug for the treatment of Alzheimer’s disease.

References

Krishna Reddy, K. V. S. R., et al. “Identification and Characterization of Potential Impurities of Donepezil.” Journal of Pharmaceutical and Biomedical Analysis, vol. 35, no. 5, Sept. 2004, pp. 1047–58, https://doi.org/10.1016/j.jpba.2004.03.022.