Hydroxy Donepezil (CAS No: 197010-20-1) or 2-[(1-Benzylpiperidin-4-yl)(hydroxy)methyl]-5,6-dimethoxyindan-1-one is a synthetic impurity of Donezepil obtained by reduction of Donepezil in presence of Lithium aluminium hydride. Donepezil drug which is a specific, selective, and potent inhibitor of acetylcholinesterase an approved drug for the treatment of Alzheimer’s disease
References
Krishna Reddy, K. V. S. R., et al. “Identification and Characterization of Potential Impurities of Donepezil.” Journal of Pharmaceutical and Biomedical Analysis, vol. 35, no. 5, Sept. 2004, pp. 1047–58, https://doi.org/10.1016/j.jpba.2004.03.022.
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