Ibuprofen EP Impurity D, CAS 938-94-3,는 2-(4-Methylphenyl)propanoic acid로, 이부프로펜의 위치 이성질체이며 분자식은 C10H12O2, 분자량은 164.2 g/mol이다. 이 아릴프로피온산계 불순물은 합성 중 이성질체 형성 또는 제조 공정에서의 위치선택적 알킬화 단계 제어 미흡으로 발생할 수 있다. 이는 니트로사민이나 돌연변이원성 종은 아니지만, 불순물 프로파일과 약전 적합성 평가에서 중요하다. 통상적인 동정은 다이오드 어레이 검출 HPLC, 질량 확인을 위한 LC-MS/MS, 그리고 필요 시 유도체화 후 구조 구분이 가능한 GC-MS에 의해 수행된다.
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