Ibuprofen EP Impurity N, 즉 Ibuprofen BP Impurity N 또는 p-Ethylhydratropic Acid는 CAS 3585-52-2의 공정 유래 불순물로, 분자식은 C11H14O2, 분자량은 178.23 g/mol이다. 구조적으로는 이부프로펜 합성 경로 또는 산화성 부반응에서 형성될 수 있는 탈알킬화 방향족 산 유사체이며, 니트로사민과 같은 전형적 유전독성 계열은 아니다. 원약과의 물리화학적 유사성이 커서 미량 확인과 정량에는 LC-MS/MS 기반의 정성 확인이 필요하며, 휘발성이 허용되는 경우 GC-MS가 보조적으로 사용된다. 약전성 불순물 평가에서는 HPLC-UV가 일상적 프로파일링에 활용된다.
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