Levetiracetam EP Impurity C는 피롤리돈, 즉 2-피롤리돈으로, CAS 142-08-5, 분자식 C5H5NO, 분자량 95.1 g/mol이다. 락탐성 헤테로고리로서 라세탐 골격과 구조적 연관성이 있으나 레비티라세탐의 아세트아미드 측쇄는 존재하지 않아, 전형적인 산화 분해산물보다는 합성 부반응물 또는 전구체 전환 기원 불순물로 해석된다. 낮은 발색성과 높은 극성 때문에 동정 및 극미량 정량에는 일반적으로 LC-MS/MS가 요구되며, 유도체화 후 GC-MS도 적용 가능하다. 규제적 평가는 공정 유래 불순물 프로파일링과 ICH 기반 불순물 관리 체계에 초점이 맞춰진다.
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