Losartan EP Impurity E, CAS 120568-11-8은 5-[2-(4-메틸페닐)페닐]-2H-테트라졸에 해당하는 메틸 치환 비페닐 테트라졸 유도체로, Losartan, Irbesartan, Candesartan의 메틸 불순물로도 불린다. 분자식 C14H12N4, 분자량 236.27 g/mol이며, 안지오텐신 II 수용체 길항제에 공통적인 비아릴 테트라졸 계열의 공정 기원 구조 유사체이다. 불완전한 아릴 결합, 메틸화된 출발물질, 또는 관련 합성 부산물로 형성될 수 있다. 방향족성과 높은 소수성, 그리고 유사한 크로마토그래피 거동 때문에 검출 및 정량에는 LC-MS/MS, LC-HRMS, HPLC-UV와 같은 직교 분석법이 일반적으로 요구된다.
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