트리페닐메탄올은 CAS 76-84-6, 분자식 C19H16O, 분자량 260.33 g/mol의 방향족 3차 벤질 알코올이다. 의약품 불순물 명명에서는 Olmesartan Trityl Alcohol, Losartan EP Impurity G, Candesartan Trityl Alcohol Impurity, Irbesartan Triphenylmethanol Impurity, Zidovudine EP Impurity D로 기재된다. 주된 기원은 트리틸 보호기의 탈보호 반응 또는 원료의약품 합성 중 트리틸 보호 중간체의 잔류이다. 이는 반응성 경보성 불순물이 아니라 비유전독성 구조적 불순물로 분류된다. 높은 소수성과 방향족 크로모포어 때문에 검출 및 정량에는 LC-MS/MS, GC-MS, 그리고 HPLC-UV 같은 직교적 방법이 통상 요구된다.
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