Metoprolol EP Impurity E는 CAS 163685-38-9로 정의되는 metoprolol의 공정 관련 불순물이다. 분자식 C15H25NO3, 분자량 267.36 g/mol이며, 비방향족 아미노알코올 구조로서 에터화, 환원적 아민화 또는 불완전한 키랄 분리 과정에서 생성되는 합성 중간체 혹은 부산물과 부합한다. 극미량 수준의 동정과 정량에는 일반적으로 역상 HPLC와 LC-MS/MS의 결합이 요구되며, 필요 시 NMR로 구조를 확인한다. 규제 관점에서는 약전 기반 관리 전략에서 지정 관련물질로 평가된다.
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