A Impureza EP E de metoprolol, CAS 163685-38-9, é uma impureza definida relacionada ao processo do bloqueador beta-adrenérgico metoprolol. Com fórmula molecular C15H25NO3 e massa molar de 267.36 g/mol, apresenta estrutura de aminoálcool não aromático compatível com intermediário sintético ou subproduto formado durante eterificação, aminação redutiva ou resolução quiral incompleta. Sua detecção e quantificação em nível traço geralmente exigem HPLC em fase reversa acoplada a LC-MS/MS, com RMN empregada para confirmação estrutural quando necessário. No contexto regulatório, é tratada como substância relacionada especificada dentro de estratégias de controle farmacopeicas.
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