La impureza EP E de metoprolol, CAS 163685-38-9, es una impureza definida relacionada con el proceso del bloqueador beta-adrenérgico metoprolol. Con fórmula molecular C15H25NO3 y peso molecular de 267.36 g/mol, corresponde a una estructura de aminoalcohol no aromático compatible con un intermedio sintético o subproducto generado durante la eterificación, la aminación reductora o una resolución quiral incompleta. Su detección y cuantificación en niveles traza suelen requerir HPLC en fase reversa acoplada a LC-MS/MS, con RMN para la confirmación estructural cuando se precisa. En el contexto regulatorio, se evalúa como sustancia relacionada especificada dentro de las estrategias de control farmacopeicas.
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