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- New Jersey, USA
- Czech Republic, EU
- Mumbai, India
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Documentation
포함 사항: HPLC, MASS/LC-MS, 1H NMR, FT-IR, 함량, 구조 규명 보고서(SER), 그리고 제품에 따라 추가 분석 데이터가 제공됩니다.
N-Nitroso Bosutinib; Synthesis Attempts and Failure Report (NAP test)
● Report Available Immediately
| 카탈로그 번호: | VE0028954 |
|---|---|
| CAS 번호: | N/A |
온라인 주문
에 대한 추가 정보
SMILES
O=NN(C1=C(C#N)C=NC2=CC(OCCCN3CCN(C)CC3)=C(OC)C=C12)C4=CC(OC)=C(Cl)C=C4ClExperiments
10 synthesis attempts under recommended conditions for nitroso impurity formation. Along with HPLC, MASS/LCMS, NMR, IR performed for all 10 experimentsReport Format
Delivered in digital PDF format. Printed copies available on request (additional shipping and handling charges apply).Report Language
English by default. Certified translations available at extra cost via our third-party translation partner.설명
EMA Guidance on Nitrosamines
According to EMA guidelines, if repeated synthesis attempts fail to detect the formation of nitrosamine impurities, it is likely that the impurity either does not exist or poses an extremely low risk.
Nitrosation
We conducted multiple nitrosation assays under rigorous forced conditions (NAP tests), to evaluate the risk of N-Nitroso Bosutinib formation. Our findings revealed that N-Nitroso Bosutinib does not readily undergo nitrosation under the expected conditions, significantly reducing concerns about its potential formation.
Request Synthesis Failure Report Quote
Our synthesis failure report provides a detailed account of the findings from our synthesis attempts and rigorous testing, demonstrating the non-formation of the nitroso impurity. It offers a comprehensive overview of the evaluated conditions and the resulting data.
N-Nitroso Bosutinib Technical Information
- Molecular Weight: 559.4 g/mol
- Molecular Formula: C26H28Cl2N6O4
- IUPAC Name: N-(3-Cyano-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinolin-4-yl)-N-(2, 4-dichloro-5-methoxyphenyl)nitrous amide
- CAS Number: N/A
- Synonyms: N/A
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Synthesis Attempts and Failure Report
Synthesis Attempts and Failure Report
Synthesis Attempts and Failure Report
Synthesis Attempts and Failure Report
Synthesis Attempts and Failure Report
Synthesis Attempts and Failure Report
Synthesis Attempts and Failure Report
Synthesis Attempts and Failure Report
Synthesis Attempts and Failure Report
Synthesis Attempts and Failure Report