N-Nitroso Diltiazem EP Impurity G, 즉 N-Nitroso O-Desacetyl-N-desmethyl Diltiazem은 벤조티아제핀계 칼슘채널 차단제인 딜티아젬에서 유래한 니트로사민 관련 공정 불순물이다. 분자식은 C19H21N3O4S, 분자량은 387.5 g/mol이며, 탈메틸화 및 탈아세틸화 중간체가 합성, 정제 또는 저장 과정에서 니트로소화 조건에 노출될 때 형성될 수 있는 N-니트로소 유도체로 해석된다. 니트로사민은 구조적 경고와 발암 우려로 인해 ICH M7에서 잠재적 유전독성 불순물로 관리된다. 극미량 검출과 정량에는 일반적으로 LC-MS/MS, 고해상도 질량분석, 그리고 휘발성이 허용될 경우 선택적 유도체화를 동반한 GC-MS가 요구된다.
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