Naphazoline EP Impurity B, CAS 86-87-3는 분자식 C12H10O2, 분자량 186.21의 중성 방향족 산소화 불순물이다. 구조적으로는 반응성이 높은 돌연변이원성 종이라기보다 벤질성 또는 아릴 에터 유래의 분해산 또는 공정 부산물에 부합한다. 약전 맥락에서는 나파졸린 제제의 관련물질 프로파일의 일부로 관리된다. 검출과 정량에는 일반적으로 역상 HPLC 기반의 분리, LC-MS 또는 GC-MS에 의한 확인, 필요 시 기준물질과의 NMR 비교가 요구되며, 이를 통해 이성질체 산소화 방향족 화합물을 구분한다.
References
Rajan, S. S. “1-Naphthaleneacetic Acid.†Acta Crystallographica Section B Structural Crystallography and Crystal Chemistry, vol. 34, no. 3, Mar. 1978, pp. 998–1000, https://doi.org/10.1107/s0567740878004641 HURWITZ, P., and J. M. THOMPSON. “USES of NAPHAZOLINE (PRIVINE(R)) in OPHTHALMOLOGY.†Archives of Ophthalmology, vol. 43, no. 4, Apr. 1950, pp. 712–17, https://doi.org/10.1001/archopht.1950.00910010723008.
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