Naphazoline Impurity 2 (Di HCl)는 이미다졸린계 혈관수축제의 불순물 프로파일에 속하는 이염산염으로, 분자식 C14H17N3.2HCl 및 분자량 227.31 2 36.46 g/mol로 기술된다. 공정 화학적으로는 나파졸린 관련 중간체 제조 중 불완전한 고리화, 측쇄 재배열, 또는 염 형성의 잔류로부터 발생할 수 있다. 양성자화된 형태는 크로마토그래피 보유와 이온화 거동을 변화시키므로 LC-MS/MS, 고분해능 MS, 필요 시 이온페어 또는 HILIC 기반 분리가 요구된다. 규제 관점에서는 구조 동정, 불순물 규격 설정, 극미량 수준의 관리가 핵심이며, NMR과 염화물 함량 분석으로 보완된다.
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