Pantoprazole EP Impurity E는 Pantoprazole BP Impurity E, Pantoprazole Related Compound E, Pantoprazole Dimer로도 불리는 이량체성 bis-benzimidazole 종으로, pantoprazole의 제조 공정과 benzimidazole sulfoxide 골격의 산화적 커플링과 관련된다. CAS 2115779-15-0, 분자식 C32H28F4N6O8S2, 분자량 764.72 g/mol에 해당한다. 구조에는 3,4-dimethoxypyridylmethylsulfinyl 치환기 2개와 difluoromethoxy기 2개가 존재하여 크로마토그래피 분리가 어렵다. 정량은 일반적으로 역상 LC-MS 또는 LC-MS/MS에 의존하며, 저농도 존재와 유사 불순물과의 공용출 가능성 때문에 UV 검출만으로는 충분하지 않은 경우가 많다.
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