Biuret (CAS 108-19-0) | também conhecido por Carbamylurea ou Imidodicarbonic diamide | é uma impureza de condensação comumente formada pela desidratação térmica de ureia; apresenta caráter sólido e solubilidade reduzida em comparação com a ureia | podendo provocar incrustações e variação no teor de nitrogênio em matérias-primas. Em controle de qualidade industrial e farmacêutico a detecção é feita por técnicas cromatográficas e espectroscópicas como HPLC | LC-MS e FTIR | além de métodos clássicos de titulação quando aplicável. Sua presença acima de limites aceitáveis compromete processos de síntese | desempenho analítico e estabilidade do produto final | demandando medidas de purificação como recristalização e lavagem para mitigação.
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